The most drastic of these were Jurkat cells, used to test a type of cancer known as acute T-cell leukemia, in which the lab tests found a cell death rate of nearly 94 percent. Aescin gel has been evaluated for use in bruising. Members of the genus Aesculus grow as trees and shrubs, often attaining heights of 23 m. The fruit is a capsule with a thick, leathery husk that contains 1 to 6 dark seeds (nuts).
The following dose has been studied in scientific research: Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). Horse chestnut seed extract may improve venous tone by improving blood flow in your legs (7, 8). Efficacy and safety on use of dried horse chestnut extract in the treatment of chronic venous insufficiency of the limbs.
DRUG INTERACTIONS: Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: "blood thinners" (e.g., warfarin, heparin), anti-platelet drugs (e.g., clopidogrel, ticlopidine), nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen, naproxen), drugs used to treat diabetes (e.g., glyburide, insulin), herbal products that may increase the risk of bleeding or low blood sugar (e.g., danshen, garlic, ginseng).Aspirin may also increase the risk of bleeding when used with this product. Doses of aescin 20 to 120 mg taken orally have been used for venous insufficiency.Pittler 2012, Suter 2006, Duration of use for the seed extract in clinical trials has been from 2 to 16 weeks, with steady state being attained after 8 twice-daily dosing intervals.Bassler 2003, Dickson 2004, Fang 2010, Pittler 2012, Intravenous aescin (5 to 10 mg) has been used in trials of postoperative edema.Sirtori 2001 Oral tinctures and topical gels containing aescin 2% are also available.Suter 2006, WHO 2004, Horse chestnut seed extract has been used in clinical trials including pregnant women with no apparent ill effects; however, in the absence of specific safety data, use in pregnancy or lactation is not recommended.WHO 2004, Because case reports of toxic nephropathy with high-dose aescin exist, horse chestnut extracts should not be coadministered with other nephrotoxic drugs such as gentamicin.WHO 2004, The coumarin derivatives found in horse chestnut extracts may potentiate warfarin, as well as interfere with highly plasma-bound drugs.Heck 2000, Scott 2002, Vogel 2005, The possibility of interference with CYP34A metabolism and P-glycoprotein transport mechanisms of other drugs exists.Hellum 2008, Renal or hepatic impairment may be relative contraindications to the use of aescin or horse chestnut derivatives.Vogel 2005 The issue of renal toxicity is uncertain.
Cochrane.Database.Syst.Rev 2006;(1):CD003230. These include a powerful antioxidant load; a potential male fertility aid; and preliminary evidence that horse chestnut extract may be able to kill some types of cancer cells. When these fibroblasts contract, they potentially induce faster wound healing. No statistical significance in the rutoside treated group versus placebo or no treatment, and in comparison with compression stockings was found.Morling 2015 No studies were found in another Cochrane review for horse chestnut rutosides in the prevention of this syndrome.Morling 2015, Horse chestnut seed extract has been shown to be effective in reducing symptoms in hemorrhoids (bleeding and swelling), bruising (pain and swelling), and postoperative edema in limited clinical trials.Reynolds 2006, Sirtori 2001, WHO 2004 Beta-aescin may have a potential antiedematous role in the management of Bell palsy; however, clinical studies are lacking.Liu 2008, Varicocele-associated infertility may on part be due to testicular oxidative stress. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. However, this awesome dietary supplement has legitimate cautions to consider, including possible side effects and medication interactions, plus dangers for pregnant or nursing women and individuals with certain health conditions.
manufacturers, food companies, and industry funders. Medical edema protection-clinical benefit in patients with chronic deep vein incompetence. If the substance has a significant impact in causing the death of those cancer cells, future research may be warranted to see if it is a potential cancer treatment.
What other names is Horse Chestnut known by? Argento A, Tiraferri E, Marzaloni M. [Oral anticoagulants and medicinal plants. Rosacea, Acne, Shingles, Covid-19 Rashes: Common Adult Skin Diseases. What’s more, horse chestnut extract may interact with the following medications (3): In addition, people with kidney or liver disease should not take horse chestnut as it may exacerbate symptoms of their disease (3). Hence, potential toxic effects of higher doses are unknown. Possibly through the same mechanisms with which horse chestnut positively impacts chronic venous insufficiency, escin seems to safely increase count and quality of sperm in men with varicocele-associated infertility, according to a 2010 research study.
Tiffany N, Ulbricht C, Bent S, and et al. You should talk with your health care provider for complete information about the risks and benefits of using this product. A test-tube study found that both aescin and horse chestnut seed extract have antioxidant properties, but that the horse chestnut seed extract had greater effects than aescin alone. Journal of Herbal Pharmacotherapy 2002;2(1):71-85. Walli, F., Grob, P. J., and Muller-Schoop, J. View abstract. Jaspersen-Schib R, Theus L, Guirguis-Oeschger M, et al. Oral doses of standardized powdered extract 250 to 312.5 mg (equivalent to aescin 100 mg) twice a day have been cited in the Complete German Commission E Monographs.WHO 2004, Aescin 20 and 50 mg tablets are available. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If the substance has a significant impact in causing the death of those cancer cells, future research may be warranted to see if it is a potential, In a laboratory setting, horse chestnut extract has shown cancer-fighting effects on cells related to leukemia, cervical cancer and breast cancer. (14), The tree is also well-suited to city growth and is one of the trees often used to line urban streets, including many in Paris, France. (18).
In most studies, the dosage used is 100–150 mg of aescin per day. Friederich, H. C., Vogelsberg, H., and Neiss, A. MISSED DOSE: If you miss a dose, take it as soon as you remember. Another benefit of horse chestnut that’s been a feature of preliminary research is its ability to help wounds heal. Schrader, E., Schwankl, W., Sieder, C., and Christoffel, V. [Comparison of the bioavailability of beta-aescin after single oral administration of two different drug formulations containing an extract of horse-chestnut seeds]. The team includes nutrition researchers, registered Morales Paris CA and Barros Soares RM.
1992;64(5):47-52. Amounts as little as 1% of a child's weight may be poisonous. Thoroughly research these precautions and consult with your health care provider before starting a new supplement regimen. Adv.Ther. View abstract. SIDE EFFECTS: Upset stomach, headache, and dizziness may occur. Animal data suggest escin to demonstrate activity in venous malfunction.Fang 2010, A clinical study (n=219) evaluated the effect of 60mg escin daily over 2 months on varicocele-associated infertility.
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